| Pair Name | Caffeic acid phenethyl ester, Cisplatin | ||
| Phytochemical Name | Caffeic acid phenethyl ester (PubChem CID: 5281787 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Caffeic acid phenethyl ester, Cisplatin | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | USP8 | hsa9101 |
| Up-regulation | Expression | PSMD9 | hsa5715 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| In Vitro Model | TOV-112D | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_3612 |
| IGROV-1/Pt1 | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_EQ62 | |
| In Vivo Model | Exponentially growing cells (1×10⁷/mouse) were inoculated i.p. or s.c. into the right flank on day 0 forming experimental groups of 7 animals. | |||
| Result | This study reveals the therapeutic potential of CAPE in cisplatin-resistant ovarian tumors as well as in tumors expressing USP8. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells. Biochem Pharmacol. 2022 Mar;197:114900. doi: 10.1016/j.bcp.2021.114900. | Click |
